A D-retro-inverso peptide designed to disrupt the FOXO4-p53 interaction that maintains senescent cell viability. Senescent cells rely on FOXO4 sequestering p53 in PML nuclear bodies to avoid apoptosis; FOXO4-DRI competitively displaces this interaction, releasing p53 to trigger intrinsic apoptosis specifically in senescent cells while sparing proliferating cells. The D-amino acid retro-inverso configuration resists protease degradation.
Research FocusSenolysis, cellular senescence, aging reversal, p53 nuclear exclusion
ReconstitutionSterile water or PBS — 5 mg/mL
Stability7 days at 2–8°C; prepare fresh when possible
Key distinction: First peptide-based senolytic — selectively eliminates senescent cells by disrupting FOXO4-p53 nuclear body sequestration. D-retro-inverso design provides protease resistance unavailable to L-peptides.
Scientific Evidence
Published Research
[1]
Baar MP et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell 2017;169:132-147 — PubMed 28340339
Research Use Only. All products sold by Lumen Peppers are intended solely for in vitro research and laboratory purposes. They are not drugs, supplements, or foods. Nothing on this page constitutes medical advice. Researchers are responsible for compliance with all applicable regulations. Last updated: April 14, 2026.