A naturally occurring nonapeptide first isolated from the cerebral venous blood of rabbits during electrically induced sleep. Despite its extremely short plasma half-life, DSIP produces sustained sleep architecture changes — selectively increasing delta-wave (stage 3/4 NREM) sleep without affecting total sleep duration or causing next-day sedation. Also modulates ACTH, cortisol, and LH secretion, suggesting neuroendocrine regulatory roles beyond sleep.
Research FocusSleep architecture, delta-wave enhancement, stress hormone modulation, circadian biology
ReconstitutionBacteriostatic water — 1 mg/mL
Stability14 days at 2–8°C
Key distinction: Selectively enhances delta-wave (deep) sleep without sedation or total sleep duration changes — the only peptide targeting sleep stage architecture rather than sleep onset or duration.
Scientific Evidence
Published Research
[1]
Schneider-Helmert D, Schoenenberger GA. Effects of DSIP in man. Multifunctional psychophysiological properties. Neuropsychobiology 1983;9:197-206 — PubMed 6353268
[2]
Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev 1984;8:83-93 — PubMed 6145143
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