A 24-amino-acid mitochondrial-derived peptide encoded within the 16S rRNA gene, discovered through a functional screen for factors that suppress Alzheimer's-associated neuronal death. Humanin binds the IGFBP3 receptor, activates STAT3 signaling via the gp130/CNTFR complex, and inhibits Bax-mediated apoptosis. Endogenous humanin levels decline with age and correlate inversely with Alzheimer's pathology and metabolic disease markers.
Research Profile
Structure24 amino acids (~2,687 Da) — encoded by mt-16S rRNA
Research FocusNeuroprotection, anti-apoptosis, Alzheimer's models, mitochondrial-derived peptide biology, aging biomarkers
ReconstitutionBacteriostatic water — 1 mg/mL
Stability14 days at 2–8°C
Key distinction: First mitochondrial-derived peptide ever discovered — endogenous levels decline with age and correlate with Alzheimer's pathology, making it both a research tool and a potential biomarker.
Scientific Evidence
Published Research
[1]
Hashimoto Y et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci USA 2001;98:6336-6341 — PubMed 11371646
[2]
Muzumdar RH et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One 2009;4:e6334 — PubMed 19623253
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