A fusion peptide combining a protein transduction domain (PTD) with a Dishevelled-binding motif (DBM) that activates the Wnt/β-catenin signaling pathway intracellularly. The PTD enables cell membrane penetration without receptor binding, while the DBM fragment stabilizes β-catenin by disrupting the Axin-Dishevelled interaction. In preclinical models, topical PTD-DBM application activates hair follicle stem cells and induces anagen (growth phase) re-entry in telogen-phase follicles.
StabilityLimited data — prepare fresh for optimal activity
Key distinction: Bypasses surface receptors entirely — the PTD delivers Wnt pathway activation directly inside the cell, representing a receptor-independent approach to β-catenin stabilization.
Scientific Evidence
Published Research
[1]
Kwack MH et al. A cell-permeable Dishevelled-binding peptide promotes hair growth. J Dermatol Sci 2018;91:214-216 — PubMed 29778318
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