A cyclic heptapeptide analog of alpha-MSH that non-selectively activates MC1R through MC5R melanocortin receptors. Unlike MC1R-selective Melanotan I, MTII's pan-receptor profile produces simultaneous tanning (MC1R), appetite suppression (MC4R), sexual arousal (MC3R/MC4R), and potential cardiovascular effects. The cyclic lactam bridge (Asp-Lys) confers metabolic stability and enhanced receptor affinity compared to linear α-MSH.
Research FocusMelanocortin receptor pharmacology, melanogenesis, appetite, sexual function crosstalk
ReconstitutionBacteriostatic water — 1 mg/mL
Stability21 days at 2–8°C
Key distinction: Pan-melanocortin agonist — simultaneous activation of MC1R through MC5R produces a unique multi-system pharmacology (skin, appetite, sexual, immune) that selective agonists cannot replicate.
Scientific Evidence
Published Research
[1]
Hruby VJ et al. Design of peptides, proteins, and peptidomimetics in chi space. Biopolymers 1997;43:219-266 — PubMed 9277134
[2]
Dorr RT et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci 1996;58:1777-1784 — PubMed 8637402
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