The only human cathelicidin — a 37-amino-acid alpha-helical peptide cleaved from the hCAP18 precursor by proteinase 3 in neutrophils. LL-37 has direct bactericidal activity against Gram-positive and Gram-negative bacteria, biofilm disruption capability, and potent immunomodulatory effects including chemokine induction, angiogenesis promotion, and wound healing acceleration. Its amphipathic alpha-helix inserts into bacterial membranes, causing rapid lysis.
Research FocusAntimicrobial defense, biofilm disruption, wound healing, innate immunity
ReconstitutionSterile water or PBS — 1 mg/mL
Stability14 days at 2–8°C; avoid repeated freeze-thaw
Key distinction: The sole human cathelicidin — the only endogenous peptide with combined direct bactericidal activity, biofilm disruption, and immune cell chemotaxis in a single molecule.
Scientific Evidence
Published Research
[1]
Vandamme D et al. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol 2012;280:22-35 — PubMed 23246832
[2]
Overhage J et al. Human host defense peptide LL-37 prevents bacterial biofilm formation. Infect Immun 2008;76:4176-4182 — PubMed 18591225
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