A modified hexapeptide angiotensin IV analog (N-hexanoic-Tyr-Ile-6-aminohexanoic amide) that potentiates hepatocyte growth factor (HGF) signaling through the c-Met receptor. Dihexa is reported to be approximately 10 million-fold more potent than BDNF in promoting synaptogenesis in vitro. It crosses the blood-brain barrier and enhances hippocampal spine density and cognitive function in animal models.
Research FocusSynaptogenesis, cognitive enhancement, HGF/Met signaling, hippocampal spine density
ReconstitutionDMSO or PEG-400 for research preparations
StabilityLimited stability data — prepare fresh
Key distinction: Reported ~10⁷-fold greater potency than BDNF for synaptogenesis — if confirmed, the most potent pro-synaptogenic compound described. Mechanism is HGF/c-Met potentiation, not direct neurotrophic receptor binding.
Scientific Evidence
Published Research
[1]
McCoy AT et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther 2013;344:141-154 — PubMed 23055539
[2]
Benoist CC et al. Oral dihexa is neuroprotective and improves cognitive deficits in aged rats. Neurobiol Aging 2014;35:2246-2253 — PubMed 24863668
Research Use Only. All products sold by Lumen Peppers are intended solely for in vitro research and laboratory purposes. They are not drugs, supplements, or foods. Nothing on this page constitutes medical advice. Researchers are responsible for compliance with all applicable regulations. Last updated: April 14, 2026.