A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and drains the cellular NAD+ pool. By blocking NNMT, 5-amino-1MQ preserves intracellular NAD+ levels and increases SAM (S-adenosyl methionine) availability. In preclinical models, NNMT inhibition reduces adipocyte size, decreases total body mass, and lowers cholesterol without affecting food intake — suggesting a direct metabolic effect independent of appetite modulation.
TargetsNNMT enzyme inhibition → NAD+ preservation, SAM increase
Research FocusNAD+ metabolism, adipocyte biology, NNMT pharmacology, metabolic regulation without appetite effects
ReconstitutionNo reconstitution — oral capsules
StabilityRoom temperature, dry storage
Key distinction: Preserves cellular NAD+ by blocking the NNMT drain — reduces fat mass without appetite suppression, representing a metabolic mechanism orthogonal to all incretin or monoamine approaches.
Scientific Evidence
Published Research
[1]
Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol 2018;147:141-152 — PubMed 29155148
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