PEGylated variant of Mechano Growth Factor where conjugation of a polyethylene glycol chain extends the plasma half-life from ~7 minutes to several days. This pharmacokinetic modification converts MGF from a locally acting autocrine signal into a systemically distributed growth factor. PEG-MGF enables sustained satellite cell activation and systemic IGF-1Ec signaling not achievable with unmodified MGF.
Research Profile
Structure24 amino acids + PEG chain (~5,000 Da total)
Research FocusSystemic vs local MGF signaling, PEGylation pharmacokinetics, skeletal muscle repair
ReconstitutionBacteriostatic water — 1 mg/mL
Stability21 days at 2–8°C
Key distinction: PEGylation converts the ultrashort-acting local MGF signal into a long-acting systemic growth factor — enabling direct comparison of autocrine vs endocrine IGF-1Ec signaling.
Scientific Evidence
Published Research
[1]
Goldspink G. Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology 2005;20:232-238 — PubMed 16024910
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