A 24-amino-acid peptide representing the C-terminal E-domain of the IGF-1Ec splice variant, expressed in response to mechanical stress in skeletal muscle. MGF activates satellite cells and initiates local muscle repair independently of hepatic IGF-1. Its extremely short half-life (~7 minutes) restricts activity to the injection site, producing autocrine/paracrine rather than endocrine effects.
TargetsSatellite cell activation, local IGF-1 receptor signaling
Research FocusMuscle satellite cell biology, mechanotransduction, local tissue repair, exercise physiology
ReconstitutionBacteriostatic water — 1 mg/mL
Stability14 days at 2–8°C
Key distinction: Ultrashort half-life (~7 min) confines activity to the injection site — enabling locally targeted satellite cell activation without systemic IGF-1 elevation.
Scientific Evidence
Published Research
[1]
Goldspink G. Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology 2005;20:232-238 — PubMed 16024910
[2]
Yang SY, Goldspink G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett 2002;522:156-160 — PubMed 12095637
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