Non-peptide, orally bioavailable ghrelin receptor agonist that eliminates the injection requirement for GH axis stimulation. Despite a 5-hour plasma half-life, MK-677 produces sustained GH and IGF-1 elevation for approximately 24 hours per oral dose.
Research Profile
StructureSmall molecule (~528 Da) — not a peptide
TargetsGHS-R1a (ghrelin receptor)
Research FocusOral GH stimulation, long-term IGF-1 elevation, sarcopenia, sleep quality
ReconstitutionNo reconstitution — oral capsules or liquid
StabilityRoom temperature, dry storage
Key distinction: Only non-peptide, orally bioavailable ghrelin receptor agonist — eliminates injection requirement while providing sustained 24-hour GH/IGF-1 elevation.
Scientific Evidence
Published Research
[1]
Nass R et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. Ann Intern Med 2008;149:601-611 — PubMed 18981485
Research Use Only. All products sold by Lumen Peppers are intended solely for in vitro research and laboratory purposes. They are not drugs, supplements, or foods. Nothing on this page constitutes medical advice. Researchers are responsible for compliance with all applicable regulations. Last updated: April 14, 2026.