A synthetic tetrapeptide derived from the active region of ciliary neurotrophic factor (CNTF), designed to mimic CNTF's neurogenic effects without binding its receptor. P21 promotes neurogenesis in the hippocampal dentate gyrus and subventricular zone by increasing BDNF expression and inhibiting leukemia inhibitory factor (LIF) signaling. Preclinical studies in Alzheimer's disease models show improved spatial memory and reduced tau hyperphosphorylation.
Research FocusAdult neurogenesis, Alzheimer's disease models, hippocampal plasticity, cognitive rescue
ReconstitutionBacteriostatic water — 1 mg/mL
Stability21 days at 2–8°C
Key distinction: Mimics CNTF neurogenic activity without receptor binding — the smallest peptide capable of promoting adult hippocampal neurogenesis through BDNF-dependent mechanisms.
Scientific Evidence
Published Research
[1]
Bolognin D et al. An experimentally driven approach to develop a small peptide with CNTF-like neurotrophic activity. PLoS One 2014;9:e89283 — PubMed 24586660
[2]
Li B et al. P21 peptide rescues cognition and normalizes tau pathology in Alzheimer's disease mouse model. Neurotherapeutics 2015;12:553-563 — PubMed 25916396
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