The biologically active C-terminal decapeptide fragment of full-length kisspeptin-54, binding the KISS1R (GPR54) receptor on hypothalamic GnRH neurons. Kisspeptin-10 is the most potent known upstream activator of the reproductive axis — a single bolus triggers robust LH and FSH pulses within minutes by stimulating pulsatile GnRH release. Its ultrashort half-life (~4 min) enables precise temporal control of HPG axis activation in research settings.
Research Profile
Structure10 amino acids (~1,302 Da) — kisspeptin(112-121) C-terminal fragment
TargetsKISS1R (GPR54) on GnRH neurons
Research FocusReproductive neuroendocrinology, GnRH pulse control, puberty onset, fertility disorders
ReconstitutionBacteriostatic water — 0.5 mg/mL
Stability14 days at 2–8°C
Key distinction: Most potent upstream trigger of the reproductive axis — directly controls GnRH pulse frequency from above the hypothalamus, unlike GnRH analogs that act at the pituitary level.
Scientific Evidence
Published Research
[1]
Dhillo WS et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab 2005;90:6609-6615 — PubMed 16174713
[2]
Jayasena CN et al. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. J Clin Invest 2014;124:3667-3677 — PubMed 25036713
Research Use Only. All products sold by Lumen Peppers are intended solely for in vitro research and laboratory purposes. They are not drugs, supplements, or foods. Nothing on this page constitutes medical advice. Researchers are responsible for compliance with all applicable regulations. Last updated: April 14, 2026.