A palmitoylated pentapeptide (Pal-KTTKS) derived from the procollagen I C-terminal propeptide cleavage sequence. The palmitic acid moiety enhances dermal penetration while the KTTKS sequence acts as a matrikine — a matrix fragment that signals fibroblasts to increase collagen I, III, and fibronectin synthesis. Double-blind clinical studies demonstrate statistically significant wrinkle depth reduction comparable to retinol without the irritation profile.
Research Profile
Structure5 amino acids + palmitic acid (~803 Da palmitoylated)
StabilityPer formulation; typically 12+ months in finished product
Key distinction: The most commercially validated cosmeceutical peptide — matrikine signaling mimics natural collagen turnover feedback. Palmitoylation solves the dermal penetration problem that limits most peptide topicals.
Scientific Evidence
Published Research
[1]
Katayama K et al. A pentapeptide from type I procollagen promotes extracellular matrix production. J Biol Chem 1993;268:9941-9944 — PubMed 8486720
[2]
Robinson LR et al. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci 2005;27:155-160 — PubMed 18492182
Research Use Only. All products sold by Lumen Peppers are intended solely for in vitro research and laboratory purposes. They are not drugs, supplements, or foods. Nothing on this page constitutes medical advice. Researchers are responsible for compliance with all applicable regulations. Last updated: April 14, 2026.